A treatment that blocks an age-related protein restored cartilage in aging and injured joints by reprogramming existing cells rather than using stem cells. Researchers at Stanford Medicine report that blocking a protein linked to aging can restore cartilage that naturally wears away in the knees

In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

  • chonglibloodsport@lemmy.worldEnglish
    211·
    3 days ago

    Wow yes. So many older and retired workers from the skilled trades could benefit from this.

    It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.

    • Damage@feddit.itEnglish
      61·
      2 days ago

      Arthritis is not limited to trade workers, anyone can have it.

      And it isn’t the only health issue physical work can cause.