How is the campaign to shut down Amazon for good, and restore the USPS? I’m a bit more interested in that.
How is the campaign to shut down Amazon for good, and restore the USPS? I’m a bit more interested in that.
Thanks for mentioning OpenEVSE (https://www.openevse.com/) I’m going to keep them in mind against future need.
I have a charger by Webasto. It has a jankety app, and way more bells and whistles than I need. Tho’ I do appreciate the 48amp rating. I chose that one because my neighbor suggested it. Turned out to not have the rebate available as our power company is rather restrictive in their choice of chargers to support. Have seen JuiceBox chargers while on drives around my state.
The citation of interest:
Deletions in the MAL gene result in loss of Mal protein, defining the rare inherited AnWj-negative blood group phenotype https://doi.org/10.1182/blood.2024025099
Key Points
The inherited AnWj-negative blood group phenotype is caused by homozygosity for a deletion in MAL, encoding Myelin and lymphocyte protein
Mal protein is expressed on red blood cell membranes of AnWj-positive, but not AnWj-negative, individuals
The genetic background of the high prevalence red blood cell antigen AnWj has remained unresolved since its identification in 1972, despite reported associations with both CD44 and Smyd1 histone methyltransferase. Development of anti-AnWj, which may be clinically significant, is usually due to transient suppression of antigen expression, but a small number of individuals with persistent, autosomally-recessive inherited AnWj-negative phenotype have been reported. Whole exome sequencing of individuals with the rare inherited AnWj-negative phenotype revealed no shared mutations in CD44H or SMYD1, but instead we discovered homozygosity for the same large exonic deletion in MAL, which was confirmed in additional unrelated AnWj-negative individuals. MAL encodes an integral multi-pass membrane proteolipid, Myelin and Lymphocyte protein (Mal), which has been reported to have essential roles in cell transport and membrane stability. AnWj-positive individuals were shown to express full-length Mal on their red cell membranes, which was not present on the membranes of AnWj-negative individuals, whether of an inherited or suppression background. Furthermore, binding of anti-AnWj was able to inhibit binding of anti-Mal to AnWj-positive red cells, demonstrating the antibodies bind to the same molecule. Over-expression of Mal in an erythroid cell-line resulted in expression of AnWj antigen, regardless of the presence or absence of CD44, demonstrating that Mal is both necessary and sufficient for AnWj expression. Our data resolve the genetic background of the inherited AnWj-negative phenotype, forming the basis of a new blood group system, further reducing the number of remaining unsolved blood group antigens.
Which is why the guy in the comic will “die single”.
I love that the biggest critique, which sounds like it was written by the ICE auto industry, is that the job of conversion must be done correctly to be safe. I mean really once converted, it’s just as dangerous to pedestrians, as any ICE car.
TIL! Been homebrewing since undergrad. First I’ve hear of Nerdbrewing. TY!
Yes, indeed. Certain opinions, of certain people, e.g. Louis DeJoy and his handlers. Or Jeff Bezos. You know, the sorts of people whose financial betterment would benefit from the demise of the USPS. And the people, mostly GOP/ Libertarian who have been misinformed about the nature of the USPS, especially those opinions.