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Have a look at this link
https://linuxways.net/mint/setup-wine-linux-mint-21/
It has steps for enabling 32 bit support, around step 2 enables and step 3 installs wine again after. You need to go through the wine install again after enabling 32 bit support (i386). If you don’t get all the packages with :i386 at the end remove wine and then install again.
With the upload, if it isn’t bittorrent it may be corrupted without being checked. Maybe look for an md5sum and confirm you have the file as expected. If the md5sum checks out you are sorted, if not you will at least know. That said it is as you say very unlikely to be the file, much more likely the libraries. Let me know how you go.
My understanding is you make fewer but more replicable mistakes. If you use a wire you have to trace it, keep the length consistent for timing reasons, use very consistent soldering technique, and ultimately you have a hard time tracing issues. With a homemade PCB you generally do get what you ask for in terms of circuitry. Traces are the right length, right thickness, right spacing, and if not then the whole board is similarly impacted, so it is obviously broken or not broken. If you mess up your design then you have a problem, but if you did the process right and you have a valid design then it works.
That all said, homemade PCB is a large time sink and modern PCB manufacture is so cheap and fast it doesn’t make sense to do at home for the most part. You can literally get a complex board faster by ordering it from halfway around the world and having it posted than making it yourself. I would say it is a good learning exercise, not a good manufacturing or prototyping practice.