To ensure games run well on Linux either via Native Linux builds or Windows games with Proton, part of the magic is in the Steam Linux Runtime. A new version of it, the Steam Linux Runtime 4.0 was recently put up with some pretty big changes.
What’s the point of it? It ensures Steam and games run through Steam on Linux work properly across all the many different Linux distributions. Another secret Valve sauce for Linux. Well, not secret at all but you get my meaning I’m sure.
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Debian separates out stuff with :[arch] suffixes, and is really flexible in the sense that it even lets you install stuff from completely different architectures for, for example, use with qemu userspace. An i386 package is going to only request i386 dependencies, unless it explicitly specifies an architecture, and vice versa. Arch Linux uses the “lib32-” prefix and I don’t really remember how it worked on Fedora but I would imagine something similar. All “gaming focused distros” are merely just their mainstream counterparts with an extra repo for a few packages, it’s not going to change fundamentals.