In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.
Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649
Would’ve been useful before I had my foot cut off. 🤷♂️
In 20 years you’ll get a pill from the pharmacy to grow a new one 😋
Depends on affordability.
TONIGHT ON DEAL OR NO DEAL:
you can get this new leg but it will cost you a kidney
I only need one kidney, AND I can have 3 legs. Deal
I already have 3 😏
But you have to rename yourself Toejam and befriend someone named Earl.
It might cost you an arm and a leg.
That means you don’t need your cartilage regrown.