In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.
Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649
I wonder if you’d have to stay off of those joints for months to allow the regrowth to occur properly.
The question is “Does 15-PGDH do something beneficial and would suppressing it have serious side effects?”
I found this:
15-HPGD has an unappreciated role in the maintenance of pregnancy. In mice, 15-HPDG has been shown to have essential roles in prevention of early termination of pregnancy and maternal morbidity. In 15-HPGD knockout mice, early pregnancy termination was detected.
So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.
reproductive urge, you mean.
Plenty of women with the equipment and no intention of using it.
Well, that’s part of what you’d have to consider. The reply didn’t state it would be contraindicated in reproductive age, just that it shouldn’t be applied without consideration.
As a 50+ year old mechanic, this can’t come soon enough.
Thank you for doing useful work
Spoiler alert: you can’t afford it.
Speak for the Americans. The rest of us have no trouble doing so
also cancer :)
Any of the “regrows damage” side of thing scares the fuck out of me. I mean I want it to come and ASAP, but I also don’t want to play chicken with C
Cancer is largely based on your genetics, except for extreme causes like asbestos or smoking. It’s worth the risk.
Not in this case.
“Stem cells survive much longer than ordinary cells, increasing the chance that they might accumulate genetic mutations. It might take only a few mutations for one cell to lose control over its self-renewal and growth and become the source of cancer.”
The news article, as well as the published work, state that:
Cartilage regeneration appears to occur through gene expression changes in pre-existing chondrocytes, rather than stem or progenitor cell proliferation.
Long-term side effects will need to researched of course and there might still be stem cells involved in the process, however that doesn’t seem to be the case according to what we know as of now.
I will gladly throw it on top of my monstrous pile of promising-looking research in hopes that it becomes a successful procedure.
Wow yes. So many older and retired workers from the skilled trades could benefit from this.
It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.
Arthritis is not limited to trade workers, anyone can have it.
And it isn’t the only health issue physical work can cause.
Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.
Or move outside the US
Or win the lottery.
I don’t think arthritis is the win you think it is.
Honestly I’d take that over this arthritis
It’s in my mouse clicker finger and starting to make video game controllers uncomfortable. Make it stop!
Uhg. Sad reality.
The rich are going to live well
So are non Americans
Holy shit. Directly treating the cause of cartilage loss with pill-form treatment in human trials right now. The shit we’ve been doing with medical science recently is fucking wild.
This summer we’ll find out the results of the Galleri test trials in the UK. Another game changer potentially.
Would’ve been useful before I had my foot cut off. 🤷♂️
In 20 years you’ll get a pill from the pharmacy to grow a new one 😋
Depends on affordability.
TONIGHT ON DEAL OR NO DEAL:
you can get this new leg but it will cost you a kidney
I only need one kidney, AND I can have 3 legs. Deal
I already have 3 😏
But you have to rename yourself Toejam and befriend someone named Earl.
It might cost you an arm and a leg.
That means you don’t need your cartilage regrown.
So…there’s a chance I can back into martial arts? Bring it.
Martial arts should probably be approached from the front, but you do you, boo.
Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.
Most definitely. I’m almost in that demographic myself and several of the slightly older, nerdy lifters at my gym talk about BPC-157 as something they would consider using.
If this gets proven to work in vivo in humans I’m certain we’ll see the same no matter side effects.
“I just popped a kneecap, it shot clean off and broke a mirror. Pill me babay!”
Between this and growing new teeth, things are looking a lot more cyberpunk than before.
In that only the upper wealthy class will be able to afford it?
Is that from a game? Kind of looks like Keanu Reeves
Cyberpunk 2077, and yeah, it’s Keanu Reeves as Johnny Silverhand.
They’ve got Idris Elba too in the DLC.
Yes and yes.
Cyberpunk 77
Damn mice’s at this point they will reach immortality first. Then again thankful for that lol.
They’ll deserve it, the shit we’ve put them through.
I feel there’s very little the rest of the world should emulate of modern Russia, but this is one example that I would like to see mimicry of: https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mouse
What the fuck? All we ever needed was a pill? Is everybody stupid?
Haahaha 😂
